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Is there more to the story : A case of 28 y/f with burning micturition

 <Disclaimer: This is an online E logbook to discuss our patient's de-identified health data shared after taking his/her/guardian's signed informed consent. Here we discuss our individual patient's problems through a series of inputs from the available global online community of experts with an aim to solve those patients' clinical problems with collective current best evidence-based inputs. This E logbook also reflects my patient-centered online learning portfolio and your valuable inputs on the comment >

This blog was prepared with the help of valuable inputs and under the guidance of Dr. Bharath

Chief complaints

A 28 yr old female, a resident of Kolkata, presented with 

  • c/o Burning micturition since 4 months
  • c/o 2 episodes of hematuria
  • c/o left groin pain since 4 months
  • c/o lower abdominal pain since 4 years
  • C/o difficulty in breathing since 4yrs
History of present illness
  • The patient reportedly contracted TB at the age of 11 yrs in 2001 after which she started experiencing easy fatigability even on doing minor forms of any physical activity resulting in difficulty in breathing and she had to turn to one side and then get up from sleeping posture
  • Since then she would occasionally experience paroxysms of cough at night accompanied by severe chest pain and throat pain which spontaneously got cured post-delivery
  • Patient reported her first encounter with the left lower abdominal pain, dull aching in nature, sudden in onset, not radiating, in the summer of May 2013 while traveling for long hours without drinking water but felt relief after drinking plenty of water and passing urine
  • Her second encounter with the pain was in year 2018 pre covid lockdown when she suddenly complained of severe agonizing pain and had to be rushed to ER at 2 am and was given some IV injections and tablets and returned home in few hours 
  • But she continued to experience occasional pains here and there which she would disregard and tried to bear with it
  • She then resorted to taking homeopathic medications prescribed for renal calculi which she took for over a period of 2 yrs all the while without ever getting an ultrasound kub or any other form of investigation done to confirm renal calculi
  • She stopped consuming homeopathic medicines for her pain abdomen but continues to take them till date for her difficulty in breathing
  • patient gave history of burning micturition and groin pain post voiding since past 4 months 
  • On 25 May, she passed visible blood in urine  and then again on 6 June she passed minute quantities of blood in urine.
Past history : 

Patient has h/o TB but not of hypertension, diabetes, asthma, epilepsy or CAD

Menstrual history 
  • Age of menarche - 13 years
  • Cycles - 45-60 days/ irregular
  • Bleeds for 4-5 days
  • Uses 2 pads per day
  • Not associated with pain abdomen
  • H/o passing clots pea sized 



Obstetrical  history
P2L1A1 
P1L1 - female child delivered through c- section ( Ix - patient request) , 6ys of age,healthy child at birth , no history of NICU admission, achieving all milestones till age

P2A1 - induced abortion@ 2 month (Ix - unwanted pregnancy) by consuming oral pills on 6/11/21 following which she experienced disturbance in her mentrual cycle with increasing frequency for next 2 months ( 6/11/21 ---->16/1/22 --->28/1/22 ---->8/2/22) for which she visited a gynecologist who advised her to get an USG done again not done and took TAB. OVRALL ( LEVONORGESTREL + ETHINYLOSTRADIOL) for 1 month and her cycles reverted back to normal


Family history
 Neither her parents nor her brother have any history of similar complaints, or Htn, dm, ba,tb
Her husband reportedly had similar complaints of lower abdominal pain and was found to have renal calculi for which he received treatment
Currently her daughter is reportedly found to have Tb


Personal history : 

  • Appetite - decreased
  • Diet - mixed
  • Bowel and bladder - Regular
  • Sleep- adequate
  • Addictions - None
  • No known food allergies

GENERAL EXAMINATION

The patient is conscious, cooperative, coherent, and well oriented to time, place, and person.

She is thin built and nourished

She has no pallor, icterus, cyanosis, clubbing, koilonychia, generalized lymphadenopathy, or pedal edema.

Vitals

  • Pulse: 92 beats per min, right radial pulse, regular, normal volume
  • Blood pressure: 110/70 mmHg, measured on the right upper arm in supine position
  • Respiratory Rate:  18 cycles per min 
  • SPO2 at room air : 98%
  • Temperature: 98 F

SYSTEMIC EXAMINATION

Abdominal system

    • No scars, sinuses, or any engorged veins.
    • Hernial orifices intact
    • Tenderness present in Left iliac fossa and hypogastric region
    • No enlargement of liver, kidneys, or spleen
    • No ascites
    • Bowel sounds were normal.
    Cardiovascular system
    • cardiac sounds  s1 and s2 heard normally
    • Apex beat located in 5th ICS, medial to the mid-clavicular line.
    • No cardiac murmurs
    • Thrills absent

    Respiratory system 







    • No chest wall deformity 
    • Trachea central
    • Expansion is symmetrical
    • Percussion note is impaired in rt 2,3,4th ICS
    • Breath sounds decreased in Right upper infra clavicular area, no wheeze or crackles heard.
    • Vocal resonance normal and symmetrical

    central nervous system

    • No focal abnormality detected
    • Higher mental functions intact 
    • Cranial nerves I- XII: No cranial nerve abnormality detected.
    • Speech normal




    • POWER

      RIGHT

      LEFT

      UL

      LL

      UL

      LL

      5

      5

      5

      5

      TONE

      NORMAL

      NORMAL

      NORMAL

      NORMAL

      LIGHT TOUCH

      NORMAL

      NORMAL

      NORMAL

      NORMAL

      POSITION

      NORMAL

      NORMAL

      NORMAL

      NORMAL

      COORDINATION

      NORMAL

      NORMAL

      NORMAL

      NORMAL


    Musculoskeletal system
    • Gait normal
    • No muscle or soft tissue changes.
    • No bone or joint deformities.
    • No limitation of movements.


    INVESTIGATIONS :

















    A 6 min walk test was performed 

    Pre walk vitals
    SPO2 -95
    BP- 100/70
    PR 86
    RR- 24

    Post walk vitals
    Spo2- 98
    Bp - 110/70
    PR- 101
    RR-34


    Provisional Diagnosis


    ?Rt upper lobe fibrosis secondary to old pul TB
    ? PID


    Treatment receiving

    • DRINK PLENTY OF ORAL FLUIDS
    • TAB. MVT PO/OD 
    • TAB ULTRACET 1/2 TAB QID 
    Discharge summary

    Discharge Date
    Date:24/06/2022
    Ward:FEMALE MEDICAL WARD
    Unit:5
    Name of Treating Faculty
    DR RAKESH BISWAS (HOD)
    DR SRI HARSHA (SR)
    DR VAMSI KRISHNA (PG II )
    DR BHARATH KUMAR PG (PGI)
    Diagnosis
    RIGHT UPPER LOBE FIBROSIS SECONDARY TO PULMONARY TUBERCULOSIS
    Case History and Clinical Findings
    A 28 yr old female, a resident of Kolkata, presented with c/o Burning micturition since 4 monthsc/o 2 episodes of hematuriac/o left groin pain since 4
    monthsc/o lower abdominal pain since 4 yearsC/o difficulty in breathing since 4yrsHistory of present
    illness:The patient reportedly contracted TB at the age of 11 yrs in 2001 after which she started
    experiencing easy fatigability even on doing minor forms of any physical activity resulting in difficulty
    in breathing and she had to turn to one side and then get up from sleeping postureSince then she
    would occasionally experience paroxysms of cough at night accompanied by severe chest pain and
    throat pain which spontaneously got cured post-deliveryPatient reported her first encounter with the
    left lower abdominal pain, dull aching in nature, sudden in onset, not radiating, in the summer of May
    2013 while traveling for long hours without drinking water but felt relief after drinking plenty of water
    and passing urineHer second encounter with the pain was in year 2018 pre covid lockdown when she
    suddenly complained of severe agonizing pain and had to be rushed to ER at 2 am and was given
    some IV injections and tablets and returned home in few hoursBut she continued to experience
    occasional pains here and there which she would disregard and tried to bear with itShe then resorted
    to taking homeopathic medications prescribed for renal calculi which she took for over a period of 2
    yrs all the while without ever getting an ultrasound kub or any other form of investigation done to
    confirm renal calculiShe stopped consuming homeopathic medicines for her pain abdomen but
    continues to take them till date for her difficulty in breathingpatient gave history of burning micturition
    and groin pain post voiding since past 4 monthsOn 25 May, she passed visible blood in urine and
    then again on 6 June she passed minute quantities of blood in urine.Past history :Patient has h/o TB
    but not of hypertension, diabetes, asthma, epilepsy or CADMenstrual historyAge of menarche - 13
    yearsCycles - 45-60 day
    s/ irregularBleeds for 4-5 daysUses 2 pads per dayNot associated with pain abdomenH/o passing
    clots pea sizedObstetrical historyP2L1A1P1L1 - female child delivered through c- section ( Ix - patient
    request) , 6ys of age,healthy child at birth , no history of NICU admission, achieving all milestones till
    ageP2A1 - induced abortion@ 2 month (Ix - unwanted pregnancy) by consuming oral pills on 6/11/21
    following which she experienced disturbance in her mentrual cycle with increasing frequency for next
    2 months ( 6/11/21 ---->16/1/22 --->28/1/22 ---->8/2/22) for which she visited a gynecologist who
    advised her to get an USG done again not done and took TAB. OVRALL ( LEVONORGESTREL +
    ETHINYLOSTRADIOL) for 1 month and her cycles reverted back to normalFamily historyNeither her
    parents nor her brother have any history of similar complaints, or Htn, dm, ba,tbHer husband
    reportedly had similar complaints of lower abdominal pain and was found to have renal calculi for
    which he received treatmentCurrently her daughter is reportedly found to have Tb
    Personal history :
    Appetite- decreasedDiet- mixedBowel and bladder- RegularSleep- adequateAddictions- NoneNo
    known food allergies
    GENERAL EXAMINATION
    The patient is conscious, cooperative, coherent, and well oriented to time, place, and person.
    She is thin built and nourished She has no pallor, icterus, cyanosis, clubbing, koilonychia, generalized lymphadenopathy, or pedal
    edema.
    Vitals
    Pulse: 92 beats per min, right radial pulse, regular, normal volume
    Blood pressure: 110/70 mmHg, measured on the right upper arm in supine position
    Respiratory Rate:18 cycles per min
    SPO2 at room air :98%
    Temperature: 98 F
    Investigation
    HAEMOGRAM
    HB 12.1 mg/dl
    TLC 8800
    N/L/E/M/B 58 /34/4/4/0
    MCV 85
    MCH 28
    PLC 1.58
    LFT
    T,BIL 1,4
    D.BIL O.28
    AST 24
    ALT 26
    ALP 138
    TOTAL PROTIEN 6.8
    ALBUMIN 4
    RFT
    S.CREAT 0.7
    B.UREA 29
    NA 141 K 4 CL 100
    CUE NORMAL
    6 MIN WALK TEST NORMAL
    URINE CULTURE AND SENSITIVITY NORMAL
    PFT SMALL AIRWAY OBSTRUCTION
    Treatment Given(Enter only Generic Name)
    DRINK PLENTY OF ORAL FLUIDSTAB. MVT PO/ODTAB ULTRACET 1/2 TAB QID
    Advice at Discharge
    1.DRINK PLENTY OF ORAL FLUIDS2.TAB. MVT PO/OD FOR 20 DAYS3.TAB ULTRACET 1/2 TAB
    QID FOR 4 DAYS4.SYP CITRALKA 10ML IN 1 GLASS OF WATER PO/TID
    When to Obtain Urgent Care
    IN CASE OF ANY EMERGENCY IMMEDIATELY CONTACT YOUR CONSULTANT DOCTOR OR
    ATTEND EMERGENCY DEPARTMENT.
    Preventive Care
    AVOID SELF MEDICATION WITHOUT DOCTORS ADVICE,DONOT MISS MEDICATIONS. In case
    of Emergency or to speak to your treating FACULTY or For Appointments, Please Contact:
    08682279999 For Treatment Enquiries Patient/Attendent Declaration : - The medicines prescribed
    and the advice regarding preventive aspects of care ,when and how to obtain urgent care have been
    explained to me in my own language

    Comments

    1. Dr Rakesh Biswas Sir Medicine HOD: Quoting @⁨Divya Mahapatra⁩ :


      A 6 min walk test was performed and was normal

      What was the 6MWT distance (and what is the normal range)?

      ReplyDelete
      Replies
      1. Sir quoting from the reference link
        https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960806/

        Normal reference value for Indian females 6MWT
        30.325 - (0.809 × age [years]) - (2.074 × weight [kg]) + (4.235 × height [cm])

        Applying to her
        30.325 - (0.809 ×28 )- (2.074× 43) + (4.235× 152)
        Applying BODMAS

        30.325 - 22.652-89.182+643.72= 562.211

        Her predicted value is then
        360/562.2= 63%
        Which is tallying with her Fvc and fev1 Values sir as we recorded in pft

        Delete
    2. [23/06, 4:39 pm] +91 96529 55915: Thanks for sharing sir.

      Just reviewed the blog and although there is history of provisional Pulmonary TB, did the patient take ATT back then?

      4 years of episodic, sudden onset left lower abdominal pain, without altered bowel habits, likely suggests a adnexal pathology, supported to some extent by the irregular menses.

      A general school of thought in Medicine is sudden pains in abdomen are either due to - something rupturing, or something getting blocked or a vascular event. Pretty sure a rupture or luminal pathology of any form would have been caught easily (such as a cyst rupture) . A vascular event like acute Mesenteric Ischemia, renal vein thrombosis are possible but signals towards either are absent. Renal vein thrombosis, gains some traction, especially with sudden pains, alleged pyuria and hematuria and a history of OCP use (need more clarity on how long and how often).

      However, can't rely too much on history and the past history of PTB surely rings alarm bells for Adnexal or Pelvic TB. However, the absence of ascites, tender organs or any USG findings makes it less likely.

      Schistosomiasis an unlikely possibility, if the patient is known to consume watercress plants (not sure about dietary Indulgences in her native place)

      What else?

      Breathlessness? Beaten down with 6MWT

      Pain abdomen - Smashed with a good abdominal exam and a reassuring USG

      Pyuria and hematuria - a cross sectional CUE gives some reassurance.

      So, to me the only other possibilities I can see are -

      Mittelschmertz
      Chronic Fatigue Syndrome/Somatization Disorder.
      [23/06, 8:29 pm] Divya Mahapatra: Sir added the radiological images

      Yes sir according to her she took whole course of ATT back then


      She took oc pills for one month only daily 2-3 months after her abortion
      [23/06, 8:51 pm] +91 96529 55915: Thanks. Just curious as to why x-rays of LS spine and Erect abdomen were ordered ?
      [23/06, 8:53 pm] Dr Rakesh Biswas Sir Medicine HOD: Spondyloarthropathy was our initial impression and we later realized her pain was more in left Iliac fossa rather than back

      ReplyDelete

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